Fluorine and fluorides

Auteur(s) : International Programme on Chemical Safety ; World Heath Organisation ; United Nations Environment Programme ; International Labour Organization

• Notice du document

  Titre / Title

  Fluorine and fluorides

  Auteur(s) / Author(s)

  International Programme on Chemical Safety, auteur principal ; World Heath Organisation, auteur principal ; United Nations Environment Programme, auteur principal ; International Labour Organization, auteur principal

  Catégorie d'ouvrage

  HISTOIRE INDUSTRIELLE ET TECHNIQUE

  Publication

  Geneva: World Health Organization, 1984

  Description technique / Physical description

  136 p.; 21 cm

• ISBN

  92-4-154096-6

  Langue / Language

  Anglais

• Description

  • Résumé / Abstract

    [Preface]

    An expert assessment of both the beneficial and toxic effects to human health posed by the use of fluorine and fluorides. Conclusions and recommendations are based on a critical analysis of well over 400 clinical and laboratory investigations. The introductory sections consider methods for the measurement of fluorides in inorganic and organic materials, sources and magnitude of exposure, and effects on health as determined through a large number of laboratory investigations. The most extensive section is devoted to a critical review of data on beneficial and toxic effects in humans. Beneficial effects of fluoride in drinking water, salt, milk, tablets, and topical applications are considered in terms of the preventive effects on dental caries and their use in the treatment of osteoporosis. Toxic effects reviewed include various forms of fluorosis, effects on renal function, hypersensitivity and dermatological reactions, and carcinogenic and teratogenic risks. On the basis of this review, the report confirms the beneficial effects of fluoride in the prevention of caries, while noting that long-term exposure to high quantities may damage enamel and bone; very high doses cause acute toxic effects and may be lethal.

  • Notes sur le contenu

    Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization